The assessment of anxiety states by rating. Anticonvulsive action of (+/-)-kavain estimated from its properties on stimulated synaptosomes and Na+ channel receptor sites. Gleitz, J., Friese, J., Beile, A., Ameri, A., and Peters, T. (+/-)-kavain inhibits the veratridine- and KCl-induced increase in intracellular Ca2+ and glutamate-release of rat cerebrocortical synaptosomes. Kavain inhibits non-stereospecifically veratridine-activated Na Extract of the kava-kava rhizome in comparison with diazepam and placebo. Botanical and dietary supplements for mood and anxiety in menopausal women. Extracts of kava (Piper methysticum) induce acute anxiolytic-like behavioral changes in mice. Central activity of aqueous extracts of Piper methysticum (kava). 2002 1.įurgiuele AR, Kinnard WJ, Aceto MD, and et al. FDA Center for Food Safety and Nutrition. Consumer advisory: kava-containing dietary supplements may be associated with severe liver injury. Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates) interacts with KAVAįood and Drug Administration.Medications changed by the liver (Cytochrome P450 2D6 (CYP2D6) substrates) interacts with KAVA.Medications changed by the liver (Cytochrome P450 1A2 (CYP1A2) substrates) interacts with KAVA.Taking kava along with alcohol might increase the risk of liver damage. This might increase the risk for some side effects, such as drowsiness and mood changes. Using kava with alcohol might increase the effects of alcohol on the central nervous system. This might increase the effects and side effects of ropinirole. Kava might decrease how quickly the liver breaks down this medication. Ropinirole (Requip) interacts with KAVA.This might increase the effects and side effects of haloperidol. Haloperidol (Haldol) interacts with KAVA.Taking kava along with a medication that can harm the liver might increase the risk of liver damage. Some medications can also harm the liver. Medications that can harm the liver (Hepatotoxic drugs) interacts with KAVA.In some cases, this might change the effects and side effects of a medication. Kava might change how these pumps work and change how much medication stays in the body. Some medications are moved in and out of cells by pumps. Medications moved by pumps in cells (P-Glycoprotein Substrates) interacts with KAVA.Medications changed by the liver (Cytochrome P450 2E1 (CYP2E1) substrates) interacts with KAVA.Medications changed by the liver (Cytochrome P450 2C9 (CYP2C9) substrates) interacts with KAVA.This could change the effects and side effects of these medications. Kava might change how quickly the liver breaks down these medications. Some medications are changed and broken down by the liver. Medications changed by the liver (Cytochrome P450 2C19 (CYP2C19) substrates) interacts with KAVA.Taking kava with sedative medications might cause breathing problems and/or too much sleepiness. Some medications, called sedatives, can also cause sleepiness and slowed breathing. Kava might cause sleepiness and slowed breathing. Sedative medications (CNS depressants) interacts with KAVA.Stop using kava at least 2 weeks before a scheduled surgery. It might increase the effects of anesthesia and other medications used during and after surgery. Surgery: Kava affects the central nervous system.
Parkinson disease: People who have Parkinson disease should avoid kava. Liver disease: People who have liver problems should avoid kava. Also, some of the chemicals in kava can pass into breast milk and might hurt a breast-fed infant. It might affect the uterus while pregnant. Pregnancy and breast-feeding: Kava is possibly unsafe when taken by mouth while pregnant or breast-feeding. Other factors may have contributed to these toxic effects. Also, past cases of liver toxicity might not be due to kava. Most people who have used kava haven't experienced liver toxicity. This seems to be rare and is most often linked to long-term use of very high doses. People might have heard that using kava can cause liver damage. "Driving-under-the-influence" citations have been issued to people driving erratically after drinking large amounts of kava tea. Do not take kava before you plan on driving. Using kava can make it difficult to drive or operate machinery safely. When taken by mouth: Kava is possibly safe when taken for up to 6 months.
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